[more info on JNX1001]

• JNX1001 is an orally active, small molecule inducer of the neurotrophic factors GDNF and BDNF
  
• Designed for once daily dosing
  
• Highly brain penetrant
  
• Mimics neurotrophic factor actions in vitro and in vivo
  
• Strong pre-clinical demonstration of potential for disease-modification in ALS and Parkinson’s disease
  
• Excellent safety and toxicology profile and PK consistent with once daily oral dosing
  
• Open INDs for ALS and PD
  
• Orphan disease designation in ALS in US and EU
  
• Well-tolerated for up to 28 weeks in healthy volunteers and PD patients at Phase I ( 4 trials, 103 people exposed) and Phase II in PD and AD (2 trials, 441 people exposed)
  
• Ready to commence clinical studies in ALS

JNX1001